Female Fertility Testing
There are various types of female fertility tests available, ranging from simple blood tests to more complex procedures, such as ultrasounds and hysterosalpingograms. The results of these tests can provide insight into a woman’s ovarian reserve, hormone levels, and reproductive anatomy.
Ovarian Reserve Testing
Loss of eggs is one of the reasons for lower fertility and higher miscarriage rates seen in women as they age. Tests to assess ovarian reserve are useful for both the physician and couple experiencing infertility as they provide a more complete understanding of the likelihood of a woman conceiving with her own eggs.
However, there are limitations to all tests such that some women with poor or abnormal results may still conceive a healthy child with their own eggs while others with normal results could still have unhealthy embryos with continued infertility. Several tests are now available to assess egg reserve.
Measuring Follicle-Stimulating Hormone (FSH) Levels
Follicle-stimulating hormone (FSH) is a hormone produced by the pituitary gland in the brain that provides an indirect measure of ovarian functioning. Test results can vary from menstrual cycle to menstrual cycle, making the results less reliable.
Measuring Anti-Mullerian Hormone (AMH) Levels
Anti-Mullerian hormone (AMH) is a hormone that is generated within the ovary and therefore considered to be a more direct measure of egg health. Unlike FSH, blood work can be obtained at any time during the cycle and the level shows less cycle-to-cycle variability.
Antral Follicle Count (AFC)
Antral follicle count (AFC) is obtained using transvaginal ultrasound measurements, usually early in the menstrual cycle. The size of the ovaries and the number of visible immature follicles present early in the cycle have been demonstrated to reflect the number of eggs that have the potential to develop during a treatment cycle.
Hysterosalpingogram (HSG)
Hysterosalpingogram (HSG) is an X-ray procedure that is useful in determining if the fallopian tubes and uterus are normally structured, and if the tubes are open.
Saline Infusion Sonogram (SIS)
A saline infusion sonogram is routinely performed to make sure that the inside of the uterus appears normal. Benign uterine growths, such as endometrial polyps or uterine fibroids, may develop in the cavity and create an environment that is hostile to embryo implantation.
Male Fertility Testing
Approximately 40% of infertility in heterosexual couples is attributable to male factors, and another 20% of infertility cases involve both female and male issues. Some of the factors may be suspected or known before attempting conception, while most might not be anticipated.
Given the significant percentage of male infertility cases associated with sperm abnormalities, a semen analysis should be among the first tests performed on aspiring parents experiencing unexplained infertility.
Common Causes of Male Infertility
Certain medical conditions or exposure to toxins can lead to damage to the sperm-producing cells or affect the release of sperm. Conditions such as undescended testes not corrected within the first year of life, cystic fibrosis, diabetes, cancer, or other chronic illnesses may also affect sperm production and/or release. Other risk factors for male infertility and/or inhibited sperm production include exposure to chemotherapy, radiation, use of supplements containing androgens (including Testosterone, DHEA, and gym workout aids), certain herbs, over-the-counter medications, and prescribed medications.
In some cases, toxin exposure or ingestion can permanently destroy the cells that produce sperm, resulting in sterility. The use of hot tubs, excessive alcohol ingestion, tobacco use, and marijuana consumption can all have adverse effects on sperm production and function. However, in other cases, there are no known exposures, health issues, or family history to account for abnormalities.
Semen Analysis Overview
The evaluation of the semen sample includes numerous factors including concentration (number) of sperm, motility (percentage of sperm moving or swimming), and morphology (sperm shape). In addition, viscosity (thickness/ability to liquefy), presence of bacteria or white blood cells, and pH are observed. Significant abnormalities in any of these parameters will decrease the likelihood of a sufficient number of sperm being able to reach or penetrate the egg.
The specimen is collected by masturbation into a collection container after abstaining from ejaculating for 2-5 days. If significant abnormalities are detected on repeated semen analysis studies, a consultation with a urologist who has special training in male infertility may be recommended.
Male Fertility Treatment Options
Treatment options vary depending on the results of the evaluation and the degree or severity of the abnormalities found on the semen test. The most important initial steps include eliminating toxin exposures (including alcohol, tobacco, illegal drugs, and any form of male hormone precursors or supplements), avoiding excess heat exposure, and maintaining a healthy diet including foods rich in folic acid and antioxidants.
A urologic evaluation may reveal a problem that can be treated medically or surgically. If alterations in lifestyle do not improve semen parameters and no medical or physical problem contributing to the poor sperm qualities can be identified, then treatment options can include sperm concentration and placement into the uterus (intrauterine insemination/IUI) or in vitro fertilization (IVF) with the injection of a single sperm into each egg (intracytoplasmic sperm injection/ICSI).